Coma, Consciousness, Cardiac Arrest; Optical Imaging of cerebral blood flow and brain metabolism; optimizing CPR; stroke; traumatic brain injury; neural monitoring devices; translational research; clinical trials

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Retinal progenitor sheet transplantation and demonstration of vision improvement in models of retinal degeneration and ultimately in retinal degeneration patients (Retinitis Pigmentosa, age-related macular degeneration)

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We study the gene networks driving neuronal diversity during brainstem development to uncover why only specific subsets are differentially affected in a given human neurologic disease. The brainstem controls multiple critical motor and sensory functions,…

Research Interests: Sensory Neurobiology, Photoreceptor physiology, Visual cycle and dark adaptation, Photoreceptor degeneration, Gene-independent therapy for visual disorders

We are a sensory neurobiology lab interested in the function of mammalian rod and cone photoreceptors. Studies target…

Cellular mechanisms of memory and epilepsy

In the Ewell Lab, we strive to uncover the network mechanisms of learning and memory in health and disease. We focus on temporal lobe epilepsy – a disease characterized by…

Our laboratory focuses on neurobiological mechanisms and regenerative medicine approaches to treat cancer and cancer therapy-related cognitive impairments (CRCI). We use molecular, cellular, genetic, and behavioral techniques to focus on the following pre-clinical research emphases:

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Gene augmentation therapy for correcting mutations in the RPE65 gene is the first FDA-approved gene therapy for any genetically inherited disease. There is no doubt that further genetic editing represents a new frontier that will permit the…

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1. Understanding oncogenic metabolic pathways in glioma stem cells (GSC) and their role in glioma progression and response to treatment. My laboratory has identified significant differences in protein processing and degradation in GSC, which…