Our research is focused on the impact of adaptive immunity, primarily T cells, on the CNS. We have two major projects in this area. First, we are studying the effect of an immune cell population called regulatory T cells (Tregs) on remyelination and CNS regeneration in models of demyelinating diseases related to multiple sclerosis. In this work, we have found that neural stem cells provoke the entry of Tregs into the CNS, helping to dampen inflammation and promote remyelination and are studying how such cells might be used to treat multiple sclerosis. Second, we are interested in the role(s) of adaptive immune cells (T and B cells) in Alzheimer’s Disease (AD), and are exploring the effect of a loss of adaptive immunity on AD progression in mouse models. Our work is geared toward understanding the crosstalk between the CNS and immune system.