Our laboratory focuses on neurobiological mechanisms and regenerative medicine approaches to treat cancer and cancer therapy-related cognitive impairments (CRCI). We use molecular, cellular, genetic, and behavioral techniques to focus on the following pre-clinical research emphases:
1) Glial complement cascade signaling mechanism in cranial radiation therapy and glioblastoma-induced neuroinflammation and cognitive dysfunction (supported by NIH).
2) Astrocyte-dependent mechanism of radiation-induced cognitive impairments and disruption of circadian rhythm (supported by American Cancer Society)
3) Human neural stem cell-based regenerative approaches to treat radiation- and chemotherapy-induced cognitive decline and synaptic damage (supported by CIRM).